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Table 1 Zinc transporters and their immunological relevance

From: Zinc deficiency as possible link between immunosenescence and age-related diseases

Protein

Distribution

Immunological relevance

References

ZnT1

Ubiquitous

-

[51]

ZnT2

Widely expressed

Mutations lead to low zinc in maternal milk and thereby neonatal zinc deficiency (humans only)

[52, 53]

ZnT3

Brain

-

[54, 55]

ZnT4

Ubiquitous

Lethal milk mutant leads to less zinc in milk and neonatal zinc deficiency (mice only, human ZnT2)

[56]

ZnT5

Ubiquitous

Loss of function leads to impaired mast cell function

[57]

ZnT6

Widely expressed

-

 

ZnT7

Widely expressed

-

[58, 59]

ZnT8

Pancreas

Autoantigen in type I diabetes mellitus

[60]

ZnT9

Brain, muscle kidney

-

[61]

ZnT10

Small intestine, liver, brain

-

[62, 63]

  1. Modified from Hara et al. 2017 [64]
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Immunity & Ageing

ISSN: 1742-4933

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