Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.

Skip to main content

Table 1 Zinc transporters and their immunological relevance

From: Zinc deficiency as possible link between immunosenescence and age-related diseases

Protein

Distribution

Immunological relevance

References

ZnT1

Ubiquitous

-

[51]

ZnT2

Widely expressed

Mutations lead to low zinc in maternal milk and thereby neonatal zinc deficiency (humans only)

[52, 53]

ZnT3

Brain

-

[54, 55]

ZnT4

Ubiquitous

Lethal milk mutant leads to less zinc in milk and neonatal zinc deficiency (mice only, human ZnT2)

[56]

ZnT5

Ubiquitous

Loss of function leads to impaired mast cell function

[57]

ZnT6

Widely expressed

-

 

ZnT7

Widely expressed

-

[58, 59]

ZnT8

Pancreas

Autoantigen in type I diabetes mellitus

[60]

ZnT9

Brain, muscle kidney

-

[61]

ZnT10

Small intestine, liver, brain

-

[62, 63]

  1. Modified from Hara et al. 2017 [64]