Fig. 6
Production pathways of differentially expressed lipids (DELs) between elderly and young mice infected of not (mock) with SARS-CoV-2. These lipids are derived from Arachidonic Acid (AA), Eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA), Docosapentaenoic acid (DPA), Linoleic Acid (LA) alpha-Linolenic acid (ALA), gamma-Linolenic acid (GLA), Dihomo-gamma-Linolenic acid (DGLA) using enzyme Cyclooxygenases (COX), lipoxygenase (LOX), cytochrome P450 (CYP), Soluble epoxide hydrolase (sEH) or non-enzymatic reaction. Fatty Acid Desaturase (FADS), Elongase, Glutathione peroxidase 4 (GPX4), Leukotriene-A4 hydrolase (LTAH), Prostaglandin E synthase (PTGES), Aldose reductase (AKR1B3) enzymes were also needed to produce some of those metabolites from Leukotriene A4 (LTA4), Prostaglandin H (PGH), Prostaglandin G (PGG), Isoleukotoxin/Leukotoxin (EpOME), Hydroperoxy Docosahexaenoic Acid (HpDHA). DELs identified belong Hydroxy Eicosatetraenoic Acids (HETE), Oxo Eicosatetraenoic Acid (oxoETE/KETE), Prostaglandin E (PGE), Prostaglandin F (PGF), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Isoprostane (IsoP), Hydroxy Octadecatrienoic Acid (HOTre), Isoleukotoxin/Leukotoxin diol (DiHOME), Hydroxy Eicosapentaenoic Acid (HEPE), Dihydroxy Eicosatetraenoic Acid (DiHETE), Epoxy Eicosatetraenoic Acid (EpETE), Hydroxy Docosahexaenoic Acid (HDPA/HDoHE), Epoxy Docosapentaenoic Acid (EpDPA/EpDPE), Dihydroxy Docosapentaenoic Acid (DiHDPA/DiHDPE), Neuroprostane (NeuroP), Resolvin D (RvD), Protectin DX (PDX) sub-class of lipids. Production pathways were built using the KEGG and WikiPathways (LIPID MAPS) database and work from Coras & al., Calder, Wen [28, 103,104,105]. The figure was created with BioRender.com