Fig. 10

Gene Set Enrichment Analysis on transcriptomic profile of mock and 5 DPI young and elderly mice against the mice Reactome Pathway database. Pathways showing significant enrichment or depletion in 5 DPI in comparison with their correspondent mock control group only in young mice (A) and only in old mice (B). Pathways showing significant enrichment or depletion in mock aged mice when compared with young mice (C). Pathways showing significant enrichment or depletion in 5 DPI old mice in comparison with young mice but not in mock group comparison (D). Pathways Count value represent number gene identified in a specific pathway and enrichment score represent the ratio between gene identified and the total number of gene in the pathway. All the pathways showing P adjusted value below 0.05 (Benjamini–Hochberg method) were displayed in panel B to D and the 25 pathways with lower P adjusted value were displayed in panel A (n = 4–5/group)