From: The relationship between biological aging and psoriasis: evidence from three observational studies
Variables | Non-psoriasis, n = 12,630 (weighted& % = 96.88) | Psoriasis, n = 343 (weighted& % = 3.12) | p-value |
---|---|---|---|
Gender | 0.786 | ||
Male | 6060 (48.8) | 163 (49.6) | |
Female | 6570 (51.2) | 180 (50.4) | |
Age | 41.50 ± 14.67 | 44.30 ± 14.11 | < 0.001** |
Race/ethnicity | < 0.001** | ||
Mexican American | 2570 (9.3) | 33 (3.5) | |
Other Hispanic | 896 (4.5) | 21 (2.9) | |
Non-Hispanic White | 5836 (67.7) | 230 (82.4) | |
Non-Hispanic Black | 2664 (12.1) | 44 (6.7) | |
Other Race—Including Multi-Racial | 664 (6.4) | 15 (4.5) | |
Education | 0.694 | ||
Did not graduate high school | 3141 (16.6) | 71 (14.8) | |
High school graduate | 3314 (25.1) | 84 (23.2) | |
Did not graduate college | 3731 (32.6) | 107 (35.0) | |
College graduate | 2444 (25.7) | 81 (26.9) | |
Annual household income | 0.821 | ||
< $20,000 | 2480 (13.5) | 77 (13.9) | |
≥ $20,000 | 10,150 (86.5) | 266 (86.1) | |
BMI | 28.41 ± 6.71 | 29.99 ± 7.07 | < 0.001** |
Smoking | < 0.001** | ||
Yes | 5520 (45.4) | 202 (59.6) | |
No | 7110 (55.6) | 141 (40.4) | |
Drinking | 0.345 | ||
Yes | 9291 (78.0) | 270 (80.8) | |
No | 3339 (22.0) | 73 (19.2) | |
Average physical activity level | 0.679 | ||
Vigorous work activity | 2837 (24.7) | 80 (26.1) | |
Moderate to low intensity work activities | 9793 (75.3) | 263 (73.9) | |
Diabetes | 0.446 | ||
Yes | 1210 (7.6) | 42 (8.9) | |
No | 11,420 (92.4) | 301 (91.1) | |
Hypertension | 0.001** | ||
Yes | 3302 (23.9) | 134 (34.1) | |
No | 9328 (76.1) | 209 (65.9) | |
Kidney disease | 0.147 | ||
Yes | 261 (1.5) | 11 (2.6) | |
No | 12,369 (98.5) | 332 (97.4) | |
Liver disease | 0.336 | ||
Yes | 373 (3.0) | 16 (3.8) | |
No | 12,257 (97.0) | 327 (96.2) | |
Thyroid disease | 0.456 | ||
Yes | 960 (8.4) | 34 (9.9) | |
No | 11,670 (91.6) | 309 (90.1) | |
Heart disease, | 0.005** | ||
Yes | 630 (4.0) | 40 (7.2) | |
No | 12,000 (96.0) | 303 (92.8) | |
Cancer | < 0.001** | ||
Yes | 786 (6.4) | 45 (12.7) | |
No | 11,844 (93.6) | 298 (87.3) | |
Systolic blood pressure (mmHg) | 119.75 ± 15.57 | 120.84 ± 15.65 | 0.157 |
Albumin (g/dL) | 4.28 ± 0.34 | 4.23 ± 0.35 | 0.023* |
Alkaline phosphatase (U/L) | 67.66 ± 22.59 | 68.76 ± 22.80 | 0.352 |
Total cholesterol (mg/dL) | 197.44 ± 41.33 | 201.40 ± 40.43 | 0.118 |
Serum glucose (mg/dL) | 5.30 ± 1.60 | 5.26 ± 1.38 | 0.690 |
Creatinine (mg/dL) | 0.88 ± 0.30 | 0.90 ± 0.18 | 0.073 |
Blood urea nitrogen (mg/dL) | 12.19 ± 4.64 | 12.73 ± 4.99 | 0.019* |
Uric acid (mg/dL) | 5.35 ± 1.37 | 5.46 ± 1.34 | 0.121 |
C-reactive protein (mg/dL) | 0.38 ± 0.75 | 0.47 ± 0.92 | 0.112 |
Glycohemoglobin (%) | 5.47 ± 0.82 | 5.48 ± 0.77 | 0.831 |
White blood cell count (1000 cells/uL) | 7.29 ± 2.14 | 7.43 ± 2.05 | 0.204 |
Lymphocyte (%) | 30.38 ± 7.83 | 29.09 ± 7.67 | 0.017* |
Red cell distribution width (%) | 12.66 ± 1.08 | 12.86 ± 1.24 | 0.004** |
Mean cell volume (fL) | 89.81 ± 5.20 | 90.19 ± 5.84 | 0.329 |
DII | 0.97 ± 1.51 | 0.93 ± 1.55 | 0.717 |
PhenoAge | 41.06 ± 15.18 | 44.64 ± 14.99 | < 0.001** |
PhenoAge advance | -0.44 ± 4.38 | 0.34 ± 4.83 | 0.001** |
PhenoAge advance acceleration | < 0.001** | ||
Yes | 5271 (37.0) | 173 (46.6) | |
No | 7359 (63.0) | 170 (53.4) | |
KDM-Age | 39.28 ± 15.26 | 42.23 ± 14.52 | < 0.001** |
KDM-Age advance | -2.22 ± 8.64 | -2.08 ± 7.58 | 0.754 |
KDM-Age advance acceleration | 0.280 | ||
Yes | 4766 (34.7) | 129 (38.0) | |
No | 7866 (65.3) | 214 (62.0) |