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Fig. 1 | Immunity & Ageing

Fig. 1

From: Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis

Fig. 1

The identification and gene-set enrichment analysis of differentially expressed genes (DEGs) between adult- and elderly-onset UC patients. a. GO analysis of DEGs was performed to identify enriched biological process, molecular function, and cell component. b. The KEGG pathway analysis of DEGs was performed using R package clusterProfiler. c. Volcano plot showed the down-regulated (blue) and up-regulated (red) DEGs in colonic tissue of elderly-onset UC compared with adult-onset UC. d-f. GSEA based on MSigDB GO (d), KEGG (e) and Reactome (f) gene sets was performed and depicted the enriched gene sets identified between adult and elderly-onset UC associated with mitochondrial function

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Immunity & Ageing

ISSN: 1742-4933

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