Table 1 Autoantibody Isotype and autoantigens found in obesity and aging
From: The role of autoantibodies in bridging obesity, aging, and immunosenescence
Antibody Isotype | Autoantigen(s) | Condition | Reference |
|---|---|---|---|
IgG | -Linked to insulin resistance: GOSR1, BTK, GFAP, ASPA, NIF3L1, PGD, ALDH16A1, KCNAB1, RNA polymerase, GSTA3 -Linked to insulin sensitivity: CTNNA1, CDC37, LGALS14, BM88, NCBP2, PDDC1, ALS2CR8, PAFAH G SUBUNIT, XRCC4 | Obesity (DIO mice) | [3] |
IgG3 | PDIA3 | Obesity (HFHF diet mice) | [15] |
IgG | MDA and adipocyte derived protein antigen | COVID-19/Obesity (patients) | [67] |
IgG | USP4, FYN, C5SD, FN1 COL1A1, BTK, GSTA3 FAD, ApoB, PIK3CB ECHDC3, KCNA10, ASPA H2AC, CARM1 hnRNPA2B1 | Obesity (human subcutaneous adipose tissue) | [71] |
IgG, IgA, IgM, IgE | Type I Interferon (IFN I) | COVID-19/aging (patients) | |
IgG | RSPH10B2, CARNMT1, PEX16, CPB1, GLUL, RSP6KA6, RPS6KA3, MRPL52 | Aging (patients) | [136] |
IgG | pSMAD2 and pSMAD3 | Aging (mice) | [171] |
IgG1 | GFAP and iba-1 reactive | Obesity (HFD mice) | [184] |
IgG | Anti-dsDNA and ANA | Obesity (lupus-prone mice) | [189] |
IgG | EPHX2, GDH1, HMGCS2, CAT, ALDHE2 | Aging (keratin knock-out mice) | [207] |
IgG1, IgG4 | cTnT, TnT3 | Aging (cognitively impaired patients) | [218] |
IgG | ATCAY. HIST1H3F, NME7, NOL3, PAIP2 | Aging (cognitively impaired patients) | [279] |
IgG | Glycosylated human serum albumin | Aging (smokers) | [316] |
IgG, IgM, IgA | CRLS1, dsDNA, ssDNA, RF | Aging (patients) | [317] |
No isotype stated | GAD65 | T2D (patients) | [318] |
IgG | RhoA and CASP3 | Maculopathy-T2D (middle-aged patients) | [319] |
IgG | Glutamate | Aging (cognitive impairment) | [320] |
IgG | Amyloid beta (Aβ); Aβ1–42 | Aging (patients) | [321] |
IgG | Anti-cell extract, ANA, | Aging (non-human primates) | [322] |