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Fig. 3 | Immunity & Ageing

Fig. 3

From: Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation

Fig. 3

Microglial activation and elevated SASP cytokines in the hypothalamus induced by HFD. (A) Representative immunohistochemistry microphotographs of the hypothalamic Iba1 + cells. (B) Density of microglial cells. (C) Average cell size of microglial cells. (D) Average cell body size of Iba1 + cells in the hypothalamus. (E) Relative mRNA expression of Il1b (F) Il18 (G) Tnf and (H) Il6 was analyzed by RT-qPCR with primers for indicated genes. Number of animals = 4–8. Student’s t-test (B, C, F, H) and Mann Whitney test (D, E, G). Data represented as mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001

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Immunity & Ageing

ISSN: 1742-4933

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