The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study

Table 5 Linear regression and binary logistic regression of plasma hs-CRP (log-transferred) with physical domain of GFI, total GFI score, and frailty (N = 3896)

	Model 1			Model 2			Model 3			Model 4			Model 5
	b/OR	95% CI	p	b/OR	95% CI	p	b/OR	95% CI	p	b/OR	95% CI	p	b/OR	95% CI	p
Physical GFI	0.07	0.05–0.10	< 0.001	0.07	0.05–0.10	< 0.001	0.06	0.04–0.09	< 0.001	0.06	0.03–0.08	< 0.001	0.03	0.01–0.06	0.005
Total GFI	0.07	0.02–0.13	0.007	0.07	0.02–0.12	0.01	0.05	-0.005-0.10	0.08	0.04	-0.01-0.09	0.1	0.02	-0.03-0.07	0.5
Frailty (GFI > = 4)	1.03	0.95–1.12	0.4	1.03	0.94–1.12	0.5	1.00	0.92–1.09	0.9	1.00	0.91–1.09	0.9	0.97	0.89–1.07	0.6

* Model 1 adjusted for age, sex; model 2, model 1 adjusted for education and living alone; model 3, model 2 adjusted for smoking status, MVPA < 150 min/week, sleep duration, alcohol consumption, and LLDS; model 4, model 3 adjusted for stroke, cancer, CKD, and lung diseases; model 5, model 4 adjusted for presence of MetS
† hs-CRP: high-sensitivity C-reactive protein; GFI: Groningen frailty indicator; MetS: metabolic syndrome; OR: odds ratio; CI: confidence interval; MVPA: Non-occupational moderate-to-vigorous physical activity; LLDS: Lifelines diet score; CKD: chronic kidney disease

ISSN: 1742-4933