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Table 1 Demographics and immune cell subsets distribution of study population (n = 363) by three age groups

From: Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis

 

 < 40 years old

(n = 158)

40–64 years old

(n = 127)

 > 64 years old

(n = 78)

p-value

Age, median (Q1, Q3)

29 (27, 34)

47 (43, 55)

70.5 (67, 76)

 < 0.001

Gender; Male, n (%)

72 (45.6%)

56 (44.1%)

29 (37.2%)

0.46

Immune cell subsets, mean (SD)

 Lymphocyte (cells/µL)

1942 (631)

1992 (668)

2069 (706)

0.38

 CD3 + T cells (%)

68.2 (7.0)

66.3 (7.4)††

60.3 (9.6)**

 < 0.001

 CD3 + T cells (cells/µL)

1324 (459)

1316 (452)

1253 (499)

0.52

 CD4 + T cells (%)

34.7 (6.5)

36.8 (7.3)

35.1 (8.7)

0.054

 CD4 + T cells (cells/µL)

682 (286)

735 (293)

731 (341)

0.26

 Naïve T cells (cells/µL)

331 (178)

303 (186)†

221 (158)**

 < 0.001

 Central memory T cells (TCM), (cells/µL)

138 (79)§

174 (114)

198 (122)**

 < 0.001

 Effector Memory T cells (TEM), (cells/µL)

192 (99)§

236 (125)

271 (213)**

 < 0.001

 Effector memory RA + T cells (TEMRA), (cells/µL)

20 (22)

22 (27)†

40 (83)*

0.003

 CD4 + CD28 + T cells (cells/µL)

624 (266)

659 (274)

642 (276)

0.55

 CD4 + CD28null T cells (cells/µL)

58 (56)

76 (86)

89 (193)

0.100

 CD4 + CD31 + T cells (cells/µL)

292 (144)

277 (122)

280 (145)

0.59

 CD8 + T cells (%)

25.0 (5.6)§§

22.3 (6.7)††

18.3 (6.9)**

 < 0.001

 CD8 + T cells (cells/µL)

480 (175)

434 (170)††

382 (219) **

 < 0.001

 Naïve T cells (cells/µL)

223 (115)§§

119 (80)††

31 (33)**

 < 0.001

 Central memory T cells (TCM), (cells/µL)

24 (33)

33 (51)

24 (38)

0.18

 Effector Memory T cells (TEM), (cells/µL)

153 (72)

167 (102)

182 (135)

0.088

 Effector memory RA + T cells (TEMRA), (cells/µL)

80 (83)

116 (106)††

145 (130)**

 < 0.001

 CD8 + CD31 + T cells (cells/µL)

344 (142)§§

285 (107)

264 (154)**

 < 0.001

 CD8 + CD28-CD57 + T cells (cells/µL)

43 (57)§§

68 (68)

84 (83)**

 < 0.001

 CD4/CD8ratio

1.48 (0.54)§§

1.87 (0.82)††

2.30 (1.34)**

 < 0.001

 CD19 + B cells (%)

14.7 (4.4)

14.0 (4.5)††

11.4 (5.5)**

 < 0.001

 CD19 + B cells (cells/µL)

285 (129)

282 (150)†

237 (148) *

0.032

 CD19 + CD20 + B cells (cells/µL)

280 (127)

279 (148)†

234 (147)*

0.036

 Naïve B cells (cells/µL)

127 (70)

131 (94)

135 (96)

0.75

 Memory B cells (cells/µL)

70 (43)

78 (48)

75 (51)

0.34

 Transitional B cells (cells/µL)

9 (11)

7 (7)

9 (10)

0.16

 NK cells (%)

14.3 (7.9)

14.5 (9.0)††

19.7 (10.4)**

 < 0.001

 NK cells (cells/µL)

279 (146)

326 (211)†

403 (244)**

 < 0.001

 NK cells/CD56 high NK cells (cells/µL)

11 (9)

12 (24)

7 (4)

0.14

 NK cells/CD56 low NK cells (cells/µL)

268 (146)

314 (208)†

396 (243)**

 < 0.001

 CD86 + monocytes (cells/µL)

399 (151)§

400 (138)†

451 (119)

0.017

 Monocytes (cells/µL)

457 (178)

453 (165)†

509 (131)

0.042

 CD14 + CD16- monocytes (M1), (cells/µL)

334 (131)

326 (120)

361 (98)

0.14

 CD14 + CD16 + monocytes (cells/µL)

14 (17)

16 (24)

20 (14)

0.053

 CD14-CD16- monocytes (M2), (cells/µL)

24 (37)

29 (49)

35 (19)

0.17

 Dendritic cells (DC), (cells/µL)

267 (141)

263 (135)

257 (100)

0.86

  1. *p ≤ 0.05: < 40 years vs. > 64 years
  2. **p ≤ 0.001: < 40 years vs. > 64 years
  3. §p ≤ 0.05: < 40 years vs. 40–64 years
  4. §§p ≤ 0.001: < 40 years vs. 40–64 years
  5. †p ≤ 0.05: 40–64 years vs. > 64 years
  6. ††p ≤ 0.001: 40–64 years vs. > 64 years
  7. P-values were all determined with the Tukey's Honestly Significant Difference (HSD) post-hoc test
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Immunity & Ageing

ISSN: 1742-4933

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