Fig. 1

Depicting global features of human immune cell atlas over the lifespan. A Schematic diagram of the scRNA-Seq data collection, processing, and analysis design. B Dot plots showing representative signature gene expression in the main immune cell types. C UMAP projection of immune cell profiles in PBMC of different age groups. D Overview of data collection datasets, clinical age groups; quantification of main cell types per patient and color-coded by main cell type. E Box plot showing distribution of main cell types across different age groups. The P values are calculated with kruskal.test. F Bar plots showing the main immune cell types from different age groups (mean ± SD). Average diversity measured with the Shannon equitability index for each tissue is shown. Point size of dot plot shows the fraction of cells with non-zero expression