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Table 2 Whole-blood myeloid cell prevalence by biological sex and chronological age

From: Monocyte-driven inflamm-aging reduces intestinal barrier function in females

 

Sex

Young adult (n = 8 M; 9 F)

Adult (n = 20 M; 21 F)

Older adult (n = 13 M; 24 F)

Mean (SD)

Median (IQR)

Mean (SD)

Median (IQR)

Mean (SD)

Median (IQR)

% CD45+leukocytes

Monocytes

Male

3.7(2.16)

3.77(1.8–5.5)

3.8(1.6)

4.11(3.1-5.0)

5.4(2.2)

4.58(3.9–6.4)

 

Female

2.8(1.5)

2.5(2-3.8)

4.36(1.51)

4.5(3-5.6)

4.4(1.5)

4.2(3.6–5.3)

Classical monocytes

Male

3.4(2.1)

3.6(1.17–4.99)

3.49(1.56)

3.9(3-4.7)

5.02(1.98)

4.1(3.7–6.1)

 

Female

2.5(1.49)

2.23(1.8–3.4)

3.96(1.4)

4.15(2.7–5.2)

4.11(1.4)

3.8(3.2–5.1)

Intermediate monocytes

Male

0.15(0.16)

0.10(0.03–0.27)

0.17(0.13)

0.15(0.06–0.25)

0.19(0.12)

0.18(0.07–0.25)

 

Female

0.16(0.12)

0.15(0.06–0.23)

0.18(0.2)

0.12(0.06–0.21)

0.15(0.11)

0.11(0.09–0.16)

Non-classical monocytes

Male

0.11(0.07)

0.11(0.04–0.19)

0.14(0.07)

0.15(0.07–0.2)

0.14(0.08)

0.14(0.07–0.19)

 

Female

0.12(0.07)

0.12(0.06–0.19)

0.10(0.07)

0.07(0.05–0.12)

0.16(0.11)

0.15(0.06–0.24)

% Monocytes

Classical monocytes

Male

86.1(14.3)

94.4(71–97)

87.9(11.1)

92.1(86–95)

93.1(3.2)

93.3(90–96)

 

Female

86.4(10.2)

89.9(76–92)

92.6(5.0)

94.2(88–96)

92.05(4.47)

92.8(89–94)

Intermediate monocytes

Male

6.0(7.6)

2.2(0.79–10.6)

5.22(3.6)

4.2(1.7–8.5)

3.4(1.9)

3.0(1.9–4.4)

 

Female

7.3(6.2)

5.4(2.6–10.5)

4.4(3.4)

3.8(1.6–6.5)

3.6(2.7)

2.9(1.9–3.5)

Non-classical monocytes

Male

5.5(6.3)

1.5(1.2–12.1)

5.3(6.4)

3.2(1.9–5.1)

3.0(1.6)

2.6(1.8–4.6)

 

Female

4.5(3.1)

3.1(2.1–7.9)

2.6(2.4)

1.8(1.3–3.1)

3.7(2.4)

3.5(1.9–4.7)

Correlations by chronological age

Variables

  

Beta

Std. Error

R2

P

 

% CD45+leukocytes

       

Monocytes

Male

 

0.038

0.01

0.17

0.006*

 
 

Female

 

0.02

0.009

0.10

0.01*

 

Classical monocytes

Male

 

0.036

0.012

0.172

0.006*

 
 

Female

 

0.023

0.005

0.11

0.01*

 

Intermediate monocytes

Male

 

0.001

0.0009

0.033

0.24

 
 

Female

 

0.0001

0.0009

0.0007

0.84

 

Non-classical monocytes

Male

 

0.000

0.000

0.01

0.49

 
 

Female

 

0.001

0.0005

0.07

0.04*

 

% Monocytes

Classical monocytes

Male

 

0.14

0.07

0.09

0.05*

 
 

Female

 

0.05

0.03

0.04

0.14

 

Intermediate monocytes

Male

 

-0.03

0.03

0.04

0.20

 
 

Female

 

-0.04

0.02

0.06

0.06

 

Non-classical monocytes

Male

 

-0.05

0.03

0.06

0.11

 
 

Female

 

-0.0007

0.01

0.00

0.96

 
  1. Top: Summary statistics of peripheral blood monocyte cell proportions in young adults (20–35 years of age), adults (36–64 years of age) and older adult (≥ 65 years of age). Bottom: Results of simple linear regression test showing how monocyte prevalence change with chronological age in males and females