Fig. 7

A Drawing of a mouse brain from a sagital view highlighting the subarachnoidal space (SAS) in red and the choroid plexus in blue. B Magnified view from the window in A where the SAS (red) can be seen infiltrating the brain above the third ventricle (3 V) and the choroid plexus (blue). C C1 and C2 include a coronal view (corresponding to the region C of the image A) of a mouse brain with a fluorescent tracer injected in the cisterna magna. The tracer (white) is distributed along the longitudinal fissure, the quadrigeminal cistern and the fissura magna. Over this image, we include the pattern of EP granules, reactive IgM.⁺ astrocytes and PAS granules in young (C1) and senescent (C2) animals. Cortex (Cx), fissura magna (FM), habenular commissure (hbc), longitudinal fissure (LF), quadrigeminal cistern (QCi), subfornical organ (SFO). A and B are adapted from [32]; C1 and C2 are adapted from [34]