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Fig. 4 | Immunity & Ageing

Fig. 4

From: Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan

Fig. 4

Correlations between cytokine levels and humoral immune responses. Correlations between cytokine levels [interferon (IFN)-γ, tumor necrosis factor (TNF), interleukin (IL)-2, IL-6, and IL-10], serum antibodies to the receptor-binding domain (RBD) of the S1 subunit of the viral spike protein [IgG(S-RBD)] levels, and neutralizing antibody activity of sera against the wild-type virus and Delta and Omicron variants (a) six months after primary vaccination and (b) three months after booster vaccination. rS: Spearman rank correlation coefficient. Values of rS are shown in bold when P values are less than 0.05: * P<0.05, ** P<0.01, and *** P<0.001. The levels of each cytokine are logarithmically transformed. The 90% confidence ellipse region was drawn assuming a near-Gaussian distribution of the values

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Immunity & Ageing

ISSN: 1742-4933

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