Skip to main content

Table 3 Cross-Sectional Associations between the NLR and CSF Outcomes in the Amyloid Positive and Amyloid Negative Subsets of the ADNI and NYU Cohorts

From: The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people

ADNI Cohort

Aβ Negative (n = 73)

Aβ Positive (n = 38)

 

Univariate Model

Adjusted Model

Univariate Model

Adjusted Model

CSF Outcome

β ± SE

p-value

β ± SE

p-value

β ± SE

p-value

β ± SE

p-value

Aβ42

0.312 ± 3.749

0.934

-3.057 ± 3.934

0.440

-2.640 ± 4.465

0.558

2.145 ± 5.173

0.682

t-tau

5.848 ± 3.221

0.074

5.620 ± 3.548

0.118

-1.473 ± 6.596

0.825

-7.596 ± 8.355

0.371

p-tau

-0.237 ± 1.471

0.872

0.197 ± 1.614

0.903

2.483 ± 4.735

0.603

-0.204 ± 6.250

0.974

NYU Cohort

Aβ Negative (n = 152)

Aβ Positive (n = 38)

 

Univariate Model

Adjusted Model

Univariate Model

Adjusted Model

CSF Outcome

β ± SE

p-value

β ± SE

p-value

β ± SE

p-value

β ± SE

p-value

Aβ42

12.538 ± 16.199

0.440

3.946 ± 16.398

0.810

9.641 ± 18.712

0.610

17.645 ± 24.974

0.486

t-tau

21.980 ± 10.619

0.040

12.015 ± 10.371

0.249

171.399 ± 38.922

 < 0.001

100.476 ± 45.914

0.037

p-tau

3.279 ± 1.364

0.017

2.453 ± 1.406

0.083

15.105 ± 4.435

0.002

8.037 ± 5.256

0.138

  1. Unadjusted and adjusted linear regression models for the association of the NLR and the three outcome variables are shown (Aβ42, t-tau, p-tau). Adjusted models included age, sex, education, race, APOE4, time between CBC and CSF exams, BMI, history of hypertension, and diabetes. Aβ positivity was defined by the CSF cut-off threshold for each cohort. β coefficients, standard errors, and p-values are shown
Back to article page

Immunity & Ageing

ISSN: 1742-4933

Contact us