Fig. 2

Proximity extension assay performed on plasma derived from PLIC cohort. A, B) Experimental design and volcano plot showing differentially circulating protein expression between homozygous LAV-BPIFB4 carriers (n = 89) and others (n = 502). B) Volcano plot, Estimate, median of the difference between homozygous LAV-BPIFB4 carriers and others; -log10 unadjusted p-value = -log 10 p-value from Wilcoxon rank sum test. Proteins showing higher and lower values in homozygous LAV-BPIFB4 carriers compared to others, reaching unadjusted p-value < 0.05, are represented in red and blue, respectively. Proteins showing no evidence of differences in terms of distribution between genotypes (unadjusted p-value ≥ 0.05) are depicted in grey. C) Bar graph indicating all differentially secreted proteins, -log10 unadjusted p-value, proteins showing higher and lower values in homozygous LAV-BPIFB4 carriers compared to others, reaching unadjusted p-value < 0.05, are represented in red and blue, respectively