Fig. 4

Senescent mesenchymal cells have higher cell − cell communications with immune cells. (a) Circles plot significant communication in each cell cluster. The thicker line indicates strong communication. (b) Heatmap of the top 20 outgoing/incoming signaling patterns in each cell cluster. (c) Chord diagram of the significant network of COLLAGEN, LAMININ, and CXCL signaling pathways in each cell cluster. (d) Bubble plot of ligand-receptor pairs in mesenchymal cell clusters. The colors in the bubble plot are proportional to the communication probability, where blue and red correspond to the smallest and largest values, respectively