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Table 3 Associations of accelerometer-assessed movement behaviors with serum biomarkers of systemic low-grade inflammation (n = 991)

From: Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study

Behavioral factors

β-coefficient (95% confidence interval), z scores of serum cytokines

Model 1#

Model 2#

Model 3#

IL-6, z-score

 Daily SB time, hours

0.06 (0.03, 0.10)‡

0.06 (0.02, 0.09)†

0.04 (-0.01, 0.10)

 Daily LPA time, hours

-0.07 (-0.12, -0.02)†

-0.06 (-0.11, -0.01)*

-0.04 (-0.10, 0.01)

 Daily MVPA time, hours

-0.13 (-0.21, -0.05)†

-0.10 (-0.18, -0.02)*

-0.08 (-0.16, 0.01)

IL-8, z-score

 Daily SB time, hours

0.05 (0.01, 0.09)*

0.05 (0.01, 0.09)*

0.05 (-0.01, 0.11)

 Daily LPA time, hours

-0.06 (-0.12, -0.01)*

-0.06 (-0.12, -0.01)*

-0.05 (-0.11, 0.01)

 Daily MVPA time, hours

-0.07 (-0.15, 0.02)

-0.08 (-0.16, -0.01)

-0.05 (-0.14, 0.04)

TNF-α, z-score

 Daily SB time, hours

0.06 (0.02, 0.09)†

0.05 (0.01, 0.08)*

0.03 (-0.02, 0.09)

 Daily LPA time, hours

-0.07 (-0.11, -0.02)†

-0.05 (-0.10, 0.00)*

-0.03 (-0.09, 0.02)

 Daily MVPA time, hours

-0.10 (-0.18, -0.02)*

-0.10 (-0.17, -0.02)*

-0.08 (-0.16, 0.01)

ICAM-1, z-score

 Daily SB time, hours

0.02 (-0.02, 0.06)

0.01 (-0.02, 0.05)

0.04 (-0.02, 0.10)

 Daily LPA time, hours

-0.04 (-0.09, 0.01)

-0.03 (-0.08, 0.02)

-0.04 (-0.10, 0.02)

 Daily MVPA time, hours

-0.01 (-0.09, 0.07)

0.01 (-0.07, 0.09)

0.04 (-0.05, 0.12)

Low-grade inflammation, composite score

 Daily SB time, hours

0.05 (0.02, 0.07)‡

0.04 (0.02, 0.07)†

0.04 (0.01, 0.08)*

 Daily LPA time, hours

-0.06 (-0.09, -0.03)‡

-0.05 (-0.09, -0.02)†

-0.04 (-0.08, -0.01)*

 Daily MVPA time, hours

-0.08 (-0.13, -0.03)†

-0.07 (-0.12, -0.01)*

-0.04 (-0.10, 0.02)

  1. #Model 1 was adjusted for age, sex, education, wear seasons, and daily wear time of ActiGraph; Model 2 was additionally adjusted for smoking, alcohol intake, APOE ε4 allele, obesity, hypertension, dyslipidemia, diabetes, stroke, and coronary heart disease; and in Model 3, the analyses of MVPA and LPA were mutually adjusted for each other and the analyses of SB were adjusted for MVPA
  2. Abbreviations: SB Sedentary behavior, LPA Light physical activity, MVPA Moderate-to-vigorous intensity physical activity, IL-6 Interleukin-6, IL-8 Interleukin-8, TNF-α Tumor necrosis factor alpha, ICAM-1 Intercellular cell adhesion molecule-1
  3. *P < 0.05, †P < 0.01, ‡P < 0.001
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Immunity & Ageing

ISSN: 1742-4933

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