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Table 4 Independent effects of interseason antibody waning and prior season post-vaccination HAI antibody titers on current season pre-vaccination HAI titersa

From: Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older

  

Model 1b Interseason titer waning

Model 2c Prior season post-vaccination titers

Vaccine Strain

Consecutive two seasons

Adjusted for prior season post-vaccination titers

Adjusted for additional covariatesc

Adjusted for interseason antibody waning

Adjusted for additional covariatesc

IAV-H3N2

2014–2015 (n = 49)

1.06 (1.04–1.08) (p < .01)

1.06 (1.04–1.08)(p < .01)

1.82 (1.65–1.99) (p < .01)

1.83 (1.67–2.01) (p < .01)

2015–2016 (n = 52)

1.21 (1.18–1.24) (p < .01)

1.21 (1.18–1.24) (p < .01)

1.98 (1.90–2.07) (p < .01)

1.98 (1.90–2.07) (p < .01)

IBV

2014–2015 (n = 49)

1.27 (1.22–1.31) (p < .01)

1.26 (1.22–1.31) (p < .01)

2.04 (1.94–2.13) (p < .01)

2.04 (1.95–2.14) (p < .01)

2015–2016 (n = 52)

1.16 (1.14–1.18) (p < .01)

1.16 (1.14–1.18) (p < .01)

2.02 (1.94–2.10) (p < .01)

2.02 (1.94–2.11) (p < .01)

IAV-H1N1

2016–2017 (n = 78)

1.17 (1.15–1.19) (p < .01)

1.17 (1.14–1.19) (p < .01)

1.91 (1.81–2.00) (p < .01)

1.92 (1.82–2.03) (p < .01)

  1. aSummary of estimated effects of interseason antibody waning adjusting for prior season post-vaccination HAI antibody titers (Model 1) and vice versa (Model 2) on current season pre-vaccination HAI antibody titers. Notes: Outcome measure is current season pre-vaccination HAI antibody titers measured using prior season vaccine strain antigens
  2. bEstimated effects are expressed as expected fold-change (95% confidence interval) in current season pre-vaccination HAI titers that is associated with a 0.1-unit less interseason antibody waning after adjusting against prior season post-vaccination HAI antibody titers (Model 1) or a two-fold increase in prior season post vaccination HAI antibody titers after adjusting against interseason antibody waning (Model 2), with or without adjusting for additional covariates (both Model 1 and 2)
  3. cAdditional covariates include age at prior study season, sex, race, and education
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Immunity & Ageing

ISSN: 1742-4933

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