Fig. 2

Age alters epididymal cell type proportions and gene expression. (A) The number of cells captured by single-cell sequencing in the epididymal initial segment of mice aged 3 and 21 months. Relative proportions of specified cell types of epithelial cells (B), extraductal stroma cells (C), and immune cells (D) among total cells. E. Distribution of differentially expressed genes (DEGs) with upregulated (E) and downregulated (F) expression in different cell types in young versus aged mice. G. Gene Ontology terms of DEGs with overall upregulated and downregulated expression