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Fig. 1 | Immunity & Ageing

Fig. 1

From: “Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation

Fig. 1

a Gating strategy used in flow cytometric analyses to gate the cells of interest after surface staining. b Representative histogram plot for unstimulated (pink) vs NP + Mi + CpG (blue) for the upregulation of costimulatory molecules CD40, CD80, and CD86 on CD11c + bone marrow-derived dendritic cells from aged mice. c Estimates of log2 fold change (log2FC) and regulation tests for costimulatory molecules expressed on cell surfaces after stimulation by various adjuvants. All treatments were applied to cells from each of six mice (n = 6) with up to three technical replicates. The horizontal axis represents adjuvants; the vertical axis represents responses; color scale represents the log2FC; asterisks represent the degree of significance: **** q < 0.001, *** q < 0.01, ** q < 0.05. Dual adjuvant combinations are omitted from the main text for conciseness. Please refer to Supplementary Fig. S1 for results of dual adjuvants and controls

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Immunity & Ageing

ISSN: 1742-4933

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