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Table 4 Association of immunity markers with risk of incident frailty in individuals without comorbidities

From: Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study

Immunity markers

Event/N (%)

Model 1

 

Model 2

 
  

OR (95% CI)

P-value

OR (95% CI)

P-value

NLR

142/956 (14.85%)

    

 Q1 (≤ 1.26)

24/232 (10.34%)

Ref

Ref

Ref

Ref

 Q2 (> 1.26, ≤1.71)

35/257 (13.62%)

1.36 (0.79, 2.39)

0.275

1.20 (0.63, 2.33)

0.580

 Q3 (> 1.71, ≤2.35)

39/241 (16.18%)

1.67 (0.98, 2.92)

0.064

1.80 (0.95, 3.45)

0.073

 Q4 (> 2.35)

44/226 (19.47%)

2.10 (1.24, 3.63)

0.007

2.88 (1.54, 5.55)

0.001

PLR

142/956 (14.85%)

    

 Q1 (≤ 71.07)

27/231 (11.69%)

Ref

Ref

Ref

Ref

 Q2 (> 71.07, ≤93.79)

38/267 (14.23%)

1.25 (0.74, 2.14)

0.401

1.17 (0.62, 2.22)

0.637

 Q3 (> 93.79, ≤126.81)

36/236 (15.25%)

1.35 (0.79, 2.33)

0.268

1.23 (0.66, 2.33)

0.514

 Q4 (> 126.81)

41/222 (18.47%)

1.71 (1.02, 2.92)

0.045

1.56 (0.84, 2.95)

0.167

SII

142/956 (14.85%)

    

 Q1 (≤ 213.61)

26/231 (11.26%)

Ref

Ref

Ref

Ref

 Q2 (> 213.61, ≤309.45)

33/258 (12.79%)

1.15 (0.67, 2.00)

0.614

1.32 (0.67, 2.65)

0.420

 Q3 (> 309.45, ≤445.76)

39/247 (15.79%)

1.44 (0.85, 2.48)

0.181

1.73 (0.90, 3.40)

0.104

 Q4 (> 445.76)

44/220 (20.00%)

1.97 (1.17, 3.37)

0.011

2.59 (1.39, 5.00)

0.003

  1. NLR: neutrophil-lymphocytes ratio, PLR: platelet-to-lymphocyte ratio, SII: systemic immune-inflammation index, OR: odds ratio, CI: confidence interval, Model 1: unadjusted, Model 2: adjusted for age, gender, BMI, smoking, alcohol assumption, educational status, marital status, regular exercise, self-reported hypertension, triglyceride, high-density lipoprotein, low-density lipoprotein and fasting blood glucose