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Table 2 Frequency of T cell subsets in the healthy controls and kidney transplant patients pre- and post-transplantation

From: Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

 

pre-Tx (N = 36)

post-Tx (N = 36)

HC (N = 27)

p value

 

pre-Tx vs post-Tx

HC vs pre-Tx

HC vs post-Tx

CD3+/Lymphocytes (%)

65.7 (59.5–74.6)

74.7 (67.3–81.5)

69.7 (67.0–74.0)

0.001

ns

0.022

CD4+/CD3+ (%)

58.9 (48.6–72.9)

52.0 (41.0–67.7)

62.1 (49.3–71.5)

0.007

ns

0.042

Naïve CD4+/CD4+ (%)

34.0 (18.8–47.8)

22.3 (13.2–36.6)

36.8 (27.8–47.8)

0.002

ns

0.005

CM CD4+/CD4+ (%)

28.0 (21.5–33.8)

25.3 (19.8–32.8)

28.7 (22.9–34.3)

ns

ns

ns

EM CD4+/CD4+ (%)

33.9 (19.3–43.0)

39.6 (26.7–51.0)

28.9 (21.3–36.9)

0.002

ns

0.004

TEMRA CD4+/CD4+ (%)

4.1 (3.0–6.3)

4.2 (3.3–7.4)

4.3 (3.1–5.9)

ns

ns

ns

Tfh CD4+/CD4 + CXCR5+ (%)

6.2 (4.0–8.9)

6.0 (3.8–10.0)

5.8 (4.0–13.0)

ns

ns

ns

Treg CD4+/CD4+ (%)

5.1 (3.8–6.6)

3.8(2.9–5.6)

5.7 (4.7–6.5)

0.005

ns

0.003

CD4 + CD28−/CD4+ (%)

2.6 (1.1–7.3)

3.6 (1.3–9.3)

1.5 (0.6–3.1)

ns

ns

0.027

Naïve CD4+/CM CD4+ ratio

1.1 (0.6–1.8)

0.8 (0.6–1.7)

1.3 (0.8–1.9)

0.036

ns

ns

Naïve CD4+/EM CD4+ ratio

1.0 (0.5–2.4)

0.6 (0.3–1.3)

1.1 (0.8–2.1)

< 0.001

ns

0.003

CD8+/CD3+ (%)

25.8 (17.4–34.6)

31.4 (21.7–45.1)

26.1 (21.3–32.2)

0.003

ns

ns

Naïve CD8+/CD8+ (%)

23.0 (16.7–53.1)

19.3 (8.6–37.9)

31.7 (18.4–53.8)

< 0.001

ns

0.019

CM CD8+/CD8+ (%)

3.4 (2.4–6.5)

2.3 (1.5–4.0)

3.4 (2.6–5.2)

< 0.001

ns

0.010

EM CD8+/CD8+ (%)

34.1 (24.0–43.8)

33.6 (22.0–47.3)

31.2 (25.3–49.8)

ns

ns

ns

TEMRA CD8+/CD8+ (%)

24.6 (17.5–34.7)

36.5 (28.2–48.9)

19.7 (13.9–34.3)

< 0.001

ns

0.002

CD8 + CD28−/CD8+ (%)

39.3 (19.3–52.8)

43.0 (21.8–65.6)

26.8 (16.7–42.8)

ns

ns

0.010

CD4+/CD8+ ratio

2.3 (1.5–3.9)

1.6 (0.9–2.8)

2.3 (1.3–3.3)

0.002

ns

0.049

  1. Abbreviations: HC healthy controls,Tx transplantation, CM central memory, EM effector memory, TEMRA effector memory T cells re-expresses CD45RA, Tfh T follicular helper cells, Treg regulatory T-cell. Median (interquartile range) of the percentage is shown. p-value more than 0.05 was regarded as non-statistically significant (ns)