Figure 1

Centenarian’s portfolio and biological mechanisms underlying the coronavirus infection. Centenarians are persons characterized by an exclusive signature resulting from the interaction between genes and environmental factors. Inflammaging identifies the low-grade inflammation status typical of the older persons that seems to drive the course of the infection. HLA genes play a crucial role in immune response and antiviral reactivity and the HLA alleles show a specific binding affinity with Sars-Cov-2 peptides