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Table 2 Immune cell number and phenotype comparisons by CKD stage

From: Emergence of T cell immunosenescence in diabetic chronic kidney disease

 

eGFR ≥60 (n = 379)

Stage 3 CKD (n = 110)

Stage 4/5 CKD (n = 34)

p value

Number CD3+

1023.2 (418.1)

964.8 (447.5)

788.0 (311.2)

0.005*

Number CD4+

604.4 (277.0)

555.3 (248.7)

450.1 (200.7)

0.003*

Number CD8+

282.8 (158.6)

293.1 (190.4)

221.4 (134.0)

0.079

CD4+ TNAIVE (%)

37.7 (14.1)

38.6 (15.6)

39.1 (16.7)

0.78

CD4+ TEFF (%)

3.2 (3.9)

3.3 (3.8)

4.7 (4.8)

0.093

CD4+ CD127+ (%)

92.4 (5.3)

90.7 (6.9)

88.4 (7.1)

< 0.001*

CD4+ CD28- (%)

7.1 (8.3)

9.0 (9.1)

7.9 (6.3)

0.12

CD4+ CD57+ (%)

4.2 (4.8)

5.3 (5.9)

5.1 (5.6)

0.096

CD8+ TNAIVE (%)

22.9 (12.5)

19.9 (12.3)

18.5 (10.4)

0.02*

CD8+ TEFF (%)

31.5 (17.5)

38.8 (19.4)

38.9 (19.6)

< 0.001*

CD8+ CD127+ (%)

55.1 (16.3)

46.9 (16.6)

47.8 (14.5)

< 0.001*

CD8+ CD28- (%)

45.2 (17.7)

54.8 (17.2)

53.8 (18.2)

< 0.001*

CD8+ CD57+ (%)

27.3 (17.4)

33.1 (20.5)

33.7 (18.0)

0.003*

Number CD68+

378.0 (146.7)

412.0 (162.8)

383.2 (159.4)

0.12

Monocyte 1 (%)

75.2 (8.9)

75.3 (9.9)

76.5 (9.1)

0.74

Monocyte 2 (%)

3.7 (1.7)

3.8 (2.4)

3.7 (1.9)

0.76

Monocyte 3 (%)

10.7 (4.7)

10.8 (7.0)

10.2 (5.7)

0.85

  1. Immune cell profiles were compared between eGFR groups. P values were calculated using one-way ANOVA. For cell subsets, the percentage of the mother cell population was used for comparison instead of cell numbers. Values are expressed as means (SD). *: p value < 0.05. eGFR, estimated glomerular filtration rate derived from the CKD-EPI formula. Stage 3 CKD, eGFR between 30 and 60; stage 4 CKD, eGFR between 15 and 30; stage 5 CKD, eGFR less than 15. Monocyte 1: classical monocytes. Monocyte 2: intermediate monocytes. Monocyte 3: non-classical monocyte
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Immunity & Ageing

ISSN: 1742-4933

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