“Inflammaging” and bone in the OsteoLaus cohort

Immunity & Ageing

Table 2 Bone parameters (fracture, BMD and TBS) according to quartiles of hs-CRP

	First	Second	Third	Fourth	P-value^a	P-value trend test^b	P-value adjusted^c
N	349	347	352	335
hs-CRP, median [IQR]	0.5 [0.3–0.6]	1.0 [0.9–1.3]	2.0 [1.7–2.3]	4.8 [3.6–7.2]
Traumatic fracture (%)	89 (25.5)	79 (22.7)	108 (30.6)	82 (24.4)	0.096		0.973
Major osteoporotic fracture (%)	31 (8.8)	43 (12.4)	41 (11.6)	31 (9.2)	0.345		0.748
Incident 5 years fractures	15/339 (4.4)	24/339 (7.1)	23/343 (5.2)	17/325 (5.2)	0.415		0.147
Spine average BMD	0.901 ± 0.154	0.916 ± 0.166	0.928 ± 0.158	0.957 ± 0.169	0.001	< 0.001	0.625
Spine average T-score	−1.32 ± 1.45	− 1.17 ± 1.56	− 1.1 ± 1.49	− 0.78 ± 1.59	< 0.001	< 0.001	0.717
Spine average TBS	1.304 ± 0.100	1.318 ± 0.102	1.326 ± 0.098	1.336 ± 0.107	0.0006	< 0.001	0.231
Femoral neck BMD	0.717 ± 0.116	0.718 ± 0.113	0.729 ± 0.104	0.752 ± 0.120	0.0002	< 0.001	0.781
Femoral neck T-score	−1.18 ± 1.04	−1.17 ± 1.02	−1.08 ± 0.94	−0.87 ± 0.18	0.0002	< 0.001	0.809
Femur total BMD	0.835 ± 0.114	0.845 ± 0.116	0.858 ± 0.115	0.879 ± 0.125	< 0.001	< 0.001	0.895
Femur total T-score	−0.88 ± 0.93	−0.79 ± 0.94	− 0.69 ± 0.93	−0.51 ± 1.02	< 0.001	< 0.001	0.823

Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variables^a, p of trend^b and after multiple adjustment^c (age, BMI, smoker, diabetes, alcohol, calcium, HRT)

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