Fig. 2

Age-dependent binding affinities between RAGE with RAGE ligands in kidney, liver and skeletal muscle. The binding levels of RAGE-RAGE ligands, which are, AGEs, HMGB1 and S100β in a kidney, b liver and c skeletal muscle of young, middle-aged, and old age mice were determined by Sandwich ELISA. Ratios in graphs represented fold of RAGE-AGEs binding levels versus young mice. **; p < 0.01 versus young mice, $$; p < 0.01 versus middle-aged mice