Figure 1

CMV and immunosenescence: Open questions. The relevance of the following questions on the role of CMV infection on immunosenescence and inflamm-aging were highlighted: 1) the need to standardize the panel of mAbs used to asses lymphocyte subsets alterations, 2) the role of each lymphoid subset in anti-CMV response, 3) the significance of CMV-induced inflammation and 4) the complexity of CMV infection in humans.