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Table 3 Percent frequency of chemokine receptor and activation marker positive leukocytes in SARS-CoV infected aged and juvenile monkeys

From: Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses

 

Frequency of cellsa

Peripheral blood

Day 1

Day 5

Day 10

 
 

Juvenile

Aged

Juvenile

Aged

Juvenile

Aged

Statistics

Monocytes

       

   CCR1

5.0 ± 0.9

1.8 ± 0.4

1.0 ± 0.1

2.2 ± 1.7

2.5 ± 0.3

2.4 ± 0.6

d.p.i*

   CCR3

1.6 ± 0.4

1.9 ± 04

1.1 ± 01

2.2 ± 12

1.1 ± 01

2.4 ± 0.6

age*

   CD86

8.9 ± 13

3.8 ± 0.4

6.3 ± 2.0

3.9 ± 1.9

4.7 ± 0.3

5.2 ± 1.6

age*

DCs

       

   CCR6

0.6 ± 0.3

0.3 ± 0.2

0.6 ± 0.2

0.0 ± 0.0

0.3 ± 01

0.2 ± 0.0

age**, d.p.i *

   CD86

1.4 ± 0.5

0.2 ± 0.0

2.9 ± 0.9

0.3 ± 0.0

0.2 ± 0.0

0.2 ± 0.0

age****

CD8 + T cells

       

CCR5

6.9 ± 1.2

2.5 ± 0.4

1.8 ± 0.3

2.0 ± 0.5

3.7 ± 0.3

9.9 ± 3.4

d.p.i**

Lung

Mock

Day 5

Day 10

 
 

Juvenile

Aged

Juvenile

Aged

Juvenile

Aged

Statistics

Macrophages

       

   CD86

20.5 ± 1.7

2.3 ± 0.1

36.4 ± 4.8

3.1 ± 1.1

34.2 ± 2.1

3.3 ± 1.7

age ****

DCs

       

   CD86

1.1 ± 0.3

0.3 ± 0.1

3.7 ± 0.5

0.4 ± 0.1

2.0 ± 0.5

0.3 ± 0.1

age ****

  1. aAverage frequency of chemokine receptor or activation marker positive cells of total perhipheral blood or lung leukocytes. Monocytes (CD14 + HLADR+), peripheral blood dendritic cells (DCs: CD14-HLADR + CD11c+), CD8 T cells (CD3 + CD8+). Lung macrophages are defined as CD68 + HLADR + and lung DCs as CD68-HLADR + CD11c+. Gating strategies are show in Additional file 1: Figure S1, Additional file 2: Figure S2 and Additional file 4: Figure S3. Statistical results of 2-way ANOVas for age and days post infection (d.p.i.) are indicated at the right with asterisks denoting degree of sigrificance: *p < 0.05, **p < 0.005 ****p < 0.0001.
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Immunity & Ageing

ISSN: 1742-4933

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