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Figure 4 | Immunity & Ageing

Figure 4

From: Characterization of recovery, repair, and inflammatory processes following contusion spinal cord injury in old female rats: is age a limitation?

Figure 4

Early TUNEL-mediated cell death was selectively increased caudal to the epicenter in aged animals. Low power representative photomicrographs of coronal spinal cord sections from aged and young animals labeled for TUNEL (blue) and counter-stained with methyl green (green) are shown (A). 3D reconstructions of TUNEL-positive quantification revealed a heterogeneous distribution of TUNEL-positive cells in both age groups (B). Stereological quantification of TUNEL-positive cells showed no significant differences between the total number of TUNEL-positive cells in aged and young animals (C). Detailed distribution analysis of TUNEL-positive cells demonstrated a single point of significance where in the caudal spinal cord region, significantly more apoptotic cells were observed in aged animals compared to the young (Student’s t test, *p< 0.05) (D). Scale bar = 100 μm.

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Immunity & Ageing

ISSN: 1742-4933

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